A Study of Quantitative Changes of the Shope Rabbit Papilloma Virus at the Site of Inoculation in the Skin of the Cottontail and Domestic Rabbit
نویسنده
چکیده
By excising after varying intervals the site of inoculation of the rabbit skin injected intracutaneously with the Shope papilloma virus and titrating its virus content, it has been shown that demonstrable active virus disappears from the skin within approximately 24 hours. The disappearance of most of the virus within such a short time as 15 to 60 minutes makes a transportation of virus from the site of inoculation as a responsible factor unlikely. The rate of disappearance seems to be the same both in the domestic and in the cottontail rabbit.
منابع مشابه
Infectiousness of the virus in Shope papillomas induced or grown in the variant rabbit strain and in a resistant species.
In the great majority of cases, the pathogenicity of the Shope papilloma virus is lost after transfer from cottontail to domestic rabbits. There is adequate evidence that the virus is present in the papillomas arising in domestic rabbits, for such animals develop neutralizing and complementfixing antibodies. :Further, the intraperitoneal inoculation of extracts of noninfectious papillomas resul...
متن کاملThe Location of In~.ctive Virus in Papillomas of the Cottontail Rabbit by Wilbur Fiske Noyes, Ph.d
A study, using the fluorcscent antibody method to locate the Shope papilloma virus antigen in the papillomas of thc cottontail and domestic rabbit, has shown the antigen to be prcscnt in demonstrable quantity only in the cells of the keratohyaline and kcratinized layers of the papillomas, with no detectable antigen in the thick, underlying layer of proliferating epithelial cells (I). Since anti...
متن کاملThe Location of In~.ctive Virus in Papillomas of the Cottontail Rabbit by Wilbur Fiske Noyes, Ph.d
A study, using the fluorcscent antibody method to locate the Shope papilloma virus antigen in the papillomas of thc cottontail and domestic rabbit, has shown the antigen to be prcscnt in demonstrable quantity only in the cells of the keratohyaline and kcratinized layers of the papillomas, with no detectable antigen in the thick, underlying layer of proliferating epithelial cells (I). Since anti...
متن کاملInfectiousness of the Shope papilloma virus after growth in embryonic, neoplastic, and cancerous states of domestic rabbit skin.
Transfer of the Shope virus from the cottontail to the domestic rabbit results in the formation of papillomas indistinguishable from those of the original host, but, in the majority of cases, such passage is associated with a loss of infectivity. The presence of virus in the domestic papillomas can be demonstrated by immunological technics, and loss of pathogenicity is referred to as masking. I...
متن کاملAre Animal Tumor Viruses Always Virus-Like?
Three tumors initiated by well characterized viruses, but in which virus is not detectable by ordinary virological techniques, are discussed. The question of the possible state of the virus within these seemingly non-infectious tumors is considered, largely from the standpoint of findings with the rabbit papilloma virus. This agent in its natural host, the cottontail rabbit, is infective, can b...
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ورودعنوان ژورنال:
- The Journal of Experimental Medicine
دوره 73 شماره
صفحات -
تاریخ انتشار 1941